Metformin HCL ER

Prescription Medication Information

This page provides information for Metformin Hydrochloride Extended-Release (ER) tablets, 500 mg. This is a prescription medication primarily indicated to improve glycemic control. In clinical practice, it may also be used as an adjunct in comprehensive weight management programs for specific patient populations when prescribed by a healthcare provider.

Critical Safety Notice

This is a prescription medication. It is not available over-the-counter and is not a standalone weight loss drug. A healthcare provider must evaluate your complete medical history, including kidney function, to determine if Metformin is safe and appropriate for you. Self-medication for weight management is dangerous and inappropriate.

Product & Usage Details

• Active Ingredient: Metformin Hydrochloride
• Dosage Strength: 500 mg per tablet
• Form: Extended-Release (ER) Oral Tablet
• Primary Indication: An adjunct to diet and exercise to improve glycemic control in adults and pediatric patients with type 2 diabetes mellitus.
• Adjunct Use in Weight Management: May be prescribed off-label by a doctor as part of a multifaceted weight management strategy that includes diet, exercise, and behavioral counseling for certain individuals, particularly those with insulin resistance or prediabetes.
• ER Benefit: The extended-release formulation is designed to slowly release medication, which may help reduce gastrointestinal side effects compared to the immediate-release version.

Essential Safety Information

• Boxed Warning: Lactic Acidosis: Metformin has a rare but serious risk of lactic acidosis, a medical emergency. Risk is increased with conditions such as renal impairment, sepsis, dehydration, and excessive alcohol intake.
• Contraindications: Contraindicated in patients with severe renal impairment, metabolic acidosis, or history of hypersensitivity to metformin.
• Administration: Typically taken once daily with the evening meal to reduce gastrointestinal upset. Do not crush or chew ER tablets.
• Potential Side Effects: Common side effects include diarrhea, nausea, vomiting, gas, weakness, indigestion, abdominal discomfort, and headache. These often subside with continued use.
• Medical Supervision: Requires regular monitoring of renal function and vitamin B12 levels, as long-term use may be associated with B12 deficiency.
• Not a Magic Pill: Any effect on weight is modest and occurs only when used in conjunction with significant lifestyle modifications under a doctors care.